Mesothelial Cell Proliferation and Biopersistence of Wollastonite and Crocidolite Asbestos Fibers
نویسندگان
چکیده
منابع مشابه
Mesothelial cell proliferation and biopersistence of wollastonite and crocidolite asbestos fibers.
The mesothelial lining is a target for the fibrotic and carcinogenic effects of mineral fibers. Fiber geometry, dimensions, chemical composition, surface reactivity, and biopersistence at the target tissue have been proposed to contribute to these toxic endpoints. We established a dose-response relationship between the number of fibers delivered to the parietal peritoneal lining, inflammation, ...
متن کاملBiopersistence of man-made vitreous fibers and crocidolite asbestos in the rat lung following inhalation.
This study investigated possible relationships between fiber bio-persistence in the lung and previously observed differences in pulmonary toxicity between asbestos and man-made vitreous fibers (MMVF) following inhalation exposure. Fischer 344/N rats were exposed nose only, 6 hr/day for 5 days to 30 mg/m3 MMVF (two fiberglass compositions, rock wool, or slag wool) or to 10 mg/m3 crocidolite asbe...
متن کاملCytotoxicity of Long and Short Crocidolite Asbestos Fibers
Fiber length and diameter are important factors in the pathogenicity of asbestos. We examined the relative toxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Both long and short crocidolite asbestos fibers were toxic to elicited macrophages in vitro. Similar to native crocidolite asbestos, long and short Tibers stimulated the release of reactive oxygen metabolites from...
متن کاملLong crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis.
Asbestos has been described as a physical carcinogen in that its carcinogenic effects appear to be related primarily to fiber dimensions. It has been hypothesized that long asbestos fibers may interfere with chromosome distribution during cell division, causing genomic changes that lead to cell transformation and neoplastic progression. Using high-resolution time-lapse light microscopy and seri...
متن کاملCrocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters.
Only a fraction of subjects exposed to asbestos develop malignant mesothelioma (MM), suggesting that additional factors may render some individuals more susceptible. We tested the hypothesis that asbestos and Simian virus (SV40) are cocarcinogens. Asbestos and SV40 in combination had a costimulatory effect in inducing ERK1/2 phosphorylation and activator protein-1 (AP-1) activity in both primar...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1997
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/38.2.173